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Dołączył: 03 Mar 2011
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 Wysłany: Śro 16:13, 09 Mar 2011 Temat postu: mbt shoes outlet eqn jot idv sjo |
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,[link widoczny dla zalogowanych]
Safety of liver warm ischemia time of the gene chip analysis
The integrity of the overall function of government , although the acute hypoxic-ischemic injury in the structure and function of the cell changes , but the level of gene regulation analysis , a variety of apoptosis-related genes is still at a low level , which means start of apoptosis Has not yet occurred. With the extended time limit ischemia and hypoxia ,[link widoczny dla zalogowanych], when the hepatic ischemia of 30min , not only the rapid hypoxic-ischemic injury may lead to HIF -1 increased significance , but also affect cell survival or cell gene expression patterns also occurred A fundamental change , a variety of cells and organelles to maintain a stable internal environment significantly decreased the level of regulation of gene expression , and a variety of genes associated with apoptosis and activation of nuclear factor significantly , upregulated ; thus suggest that the liver continued to suffer 30min of warm ischemia ,[link widoczny dla zalogowanych], it may inevitably lead to cell death phenomenon. Therefore , it is true , some scholars clinical outcome after liver surgery according to the experience of human liver tolerance to warm ischemia suggested time limit may be extended over time , but the liver after ischemic injury suffered in the dynamic change of gene expression analysis of liver tolerance to warm ischemia Should as far as possible the safety limit control in critical genes such as APAF death of a 1, PDCD10, FBX5, DFF40, DFFA so obvious activation was significantly increased ,[link widoczny dla zalogowanych], and the antiapoptotic gene XI-AP, survivin was down before such , That is good before hepatic ischemia 30min . Also suggest a HIF 1, APAF a 1, PDCD10, XIAP, survivin ,[link widoczny dla zalogowanych], are likely to affect the ischemia and hypoxia as the severity of liver injury landmark genes, analysis of different time of liver ischemia induced apoptosis in liver cell injury Significance of the occurrence .
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