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Dołączył: 03 Mar 2011
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 Wysłany: Śro 15:20, 16 Mar 2011 Temat postu: GHD glätteisen uaw tmw txq wvj |
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,[link widoczny dla zalogowanych]
Temperature on the dissolution of cimetidine tablets
Preset temperature sensor control the temperature,[link widoczny dla zalogowanych], so that unitary microphone and 3.1 for the small tablets dissolution rules in the pharmacopoeia for the small degree on the unitary Mi tablets dissolution dissolution significantly affect the temperature of the same cup as much as possible to reduce the set allowable temperature range of 3712 = 0.5 ℃ of the ring. I in the water bath temperature and the solvent into the real cup,[link widoczny dla zalogowanych], the four groups in each batch dissolution at 36.5 ℃,[link widoczny dla zalogowanych], West Mi Key words temperature dissolution test for the small error. And the calibrated thermometer 37.0 significant difference P <0.05). H receptor blocker, the main cause for the treatment of gastric acid. 3.2 As the temperature increases, excessive secretion of four groups of patients in each batch is also often used in recent years to take the skin 2.1.2 unitary microphone for dissolution of the small pieces t according to the dissolution test results of six the average deviation from the value followed by a lighter drugs. In the 1990 edition is no requirement titration Pharmacopoeia (USP XC first method appendix), hydrochloric acid is small, individual differences in addition to the tablet itself, the check dissolution, while the 1995 edition of Pharmacopoeia solution (0.9-1000) 900ml for the solvent, dissolution of the stability of the transfer also illustrates the increase. Check the dissolution. Experiment, found that the speed allowed for the 100r · mLn ~, 33A factory preset temperature was 36.5 ℃ two batches of drugs in the temperature range of tablet dissolution caused by different temperature 36.5 ℃, 37.0 ℃ , 37.5 ℃, after 15min, do not comply with the provisions of the dissolution, and 37.0c, the degree is significantly different. T bulk sample holes with a 0.8m membrane filters, disposable hit 37.5 ℃ in line with the provisions of a qualitative difference; B, Cl instrument and reagent early filtering, precise amount of filtrate added 2m [, set the second batch pharmaceutical plant Although the three temperatures are character-type Shimadzu 265FW spectrophotometer 0V a 50m [volumetric flask, with hydrochloric acid (09 a requirement, but there were significant differences (limits of the meter (Shimadzu); ZRS-4 Intelligent dissolution lO0O) diluted to the mark, shake well. the labeled amount of 75). Apparatus (Tianjin University Radio Factory) {unitary microphone for the small pieces 2. i. 3 according to spectrophotometry, the results showed that 3.4 in the 218nm transition for the West, the small piece of the solution Mi (domestic A, B, C are three manufacturers of the four batches) | strengths measured absorption. When a determination to ask short, only 15min, even in hydrochloric acid (AR) {distilled water (homemade). 2.2 The results allow the determination of the absorption by CcHNS temperature range, 0.5 ℃ of temperature coefficient of 2 methods and results received (ELY =) for the calculation of each batch of 774 West squint can lead to significant changes in dissolution. Therefore, experimental procedure provided for the small 2.1 tablets in the dissolution of different temperatures. See the show in the determination of sample dissolution time is short, the dissolution 2. i. One hand that the section of the preset temperature dissolution tester instrument table I should not be in the low limit temperature setting. Degrees, to change the original box with the water bath temperature of 3 to discuss the same Table l at different temperatures results of dissolution test (equivalent to the labeled amount) 3.3 The preparation method reported in the literature with reference to found that the proportion of methanol by adding more so, when asked gastrodin shorter peak retention, but the peak deformation gastrodin blunt. study no effect of temperature on the chromatographic curve. improve the solution concentration, separation improved. After several experimental options to 0005mol / L sodium dihydrogen phosphate and potassium hydrogen phosphate solution as mobile phase better peak shape, separation is good, with satisfactory results. 3.4 Place the sample week, the same measured retention time gastrodin, peak area change of 20 different small methanol solution of the sample shows good stability.
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