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Wysłany: Śro 13:07, 23 Mar 2011
Temat postu: p90x calendar won vzu llr fhb
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, MDA and brain water content was significantly higher (P Rb 1.05), abnormal changes ultrastructure; XNJI after treatment, the above-mentioned abnormal changes of each index was significantly reduced compared with the control group there was significant difference (P0D5) . Conclusion XNJI acute severe CO poisoning, have good therapeutic effect,
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, the mechanism and enhance the body No level,
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, decrease the level of ET and oxygen free radicals. Keywords Co poisoning XNJI oxygen free radical nitric oxide endothelin AbstractObjectiveToinvestigatetheeffectsofxingnaojinginjection (XNJI) intreatingacuteseverecarbonmonoxide (Co1poisoninganditsmechanism.Methods60Sprague-Dawleymaleratswererandomlydividedintocon-trolgroupandXNJI-treatedgroup, changesofseveralparametersweredynamicallyobservedinplasmaandbrain, whichincludedncoxide (No), endothelin (ET), malondialdehyde (MD,
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, supemxidedismutase (SOD) andwaterCOn-tentandultrastructureofbrain.ResultsNOlevelandSODactivityinplasmaorcerebraltissuealldecreasedsignifi-candy (PI_05),
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, ETlevelandMDAcontentinplasmaorcerebraltissueincreasedremarkably (P <0.05), watercontentofbraintissueacceleratedprominentlytoo (P <0.05), andtherewereobviouslyalmormalckinbrainultrastructure.XNJIadministered, theabnormalchangesofindexesasabovewereamelioratedmarkedly, andthereWassignificantdigferencebetweencontrolgroupandXNJI-treatedgroup (P <0.05). ConclusionXNJIcouldeffectivelyprotectthebrain Qiu DmacuteCOpoisoning, themechanismWasrelatedtoitsraisingNolevelandreducingEToroxygen mound eeradicakKeyWordsXingnaqingin} e ': Ii0nCarbonmo ~ xidepoisoningNitr ~ oxideEnclaIheI.nOxygenfree depression c cracking c {| Is XNJI compound as a proprietary Chinese medicine, has been widely used to rescue the central nervous system treatment of critical illness and has received good results. but its role in the treatment of carbon monoxide poisoning mechanism rarely reported in detail. In this experiment, rat model of acute severe CO poisoning, and of XNJI acute treatment of moderate to severe CO poisoning and its possible mechanism. 1 61.1 Materials and methods Animals and experimental groups: male Spra solid lD) rats (Experimental Animal Center of Fourth Military Medical University to provide) 60, weighing 350 ~ 1og. randomly divided into two groups: CO poisoning in the control group, 30, modeling the exposure before and immediately after successful intravenous saline were 1.Om # kg; Ⅺ dumb group, 3o only, will be replaced by normal saline Ⅺ dumb (Wuxi Pharmaceutical Co bilge Hill Road Wo c 【z101m are the same as the control group.
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