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| ential target for a new class of anti-amyloid therapies." Greengard won the 2000 Nobel Prize in Physiology or Medicine for research into how neurons communicate.Scientists have been searching for ways to reduce beta-amyloid production in Alzheimer's patients by blocking gamma-secretase, but most gamma-secretase inhibitors also block the cleavage (split,uggs for kids outlet, split) of an important immune system molecule called Notch. Notch plays a pivotal role (key role) in the development of blood-forming organs and the immune system. Earlier research by Greengard and his colleagues showed that Gleevec,rain boots, a drug used to treat leukemia (leukemia) and gastrointestinal (GI's) stromal (matrix a) tumors, successfully inhibited the ability of gamma secretase to form beta amyloid without affecting the Notch pathway.In the new study, led by Gen He,uggs outlet for kids, a research associate in Greengard's lab, the researchers showed that GSAP stimulates production of beta-amyloid in cell lines, and that reducing GSAP reduces beta-amyloid. The researchers also looked at GSAP's action in a mouse model of Alzheimer's disease. They knocked down the gene that codes for GSAP using RNA interference, and found that levels of beta-amyloid as well as plaque development decreased. Biocheyilai：
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