 Wysłany: Sob 22:43, 12 Mar 2011 Temat postu: zqq iyv grk jov |
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| Menopause and sex hormones on blood lipids of elderly women
reaseinFSH, LH, andslightdecreaseinPRL (P 0.05). ThechangesinlipldsandEwerecorrelatedwiththest-yleandagewhenmenopauseappears. andcheeffectofsurgicalmenopauseisgreaterthanthatofnaturalone. On】 YE25howedcorrelatlonwith1ipids, andchecorrelationcoefficientofEiwthTO, LDL-C, HDL-Cwere-O. 44, a 0.54,0.43 respectively (P <0.001). ThestudysuggeststhaithepostmenopausalchangeoflipidsisduetodecrezseinE2, andovariesshouldbepreserved, wheneverpossible, ifperimenopausalwomenreceivepelvicoperation. KeyWords: AgedMenopauseSexhormonesHyperlipidemia Pingyangmycin combination with verapamil on pulmonary fibrosis in the PLA. Lane Department of Pathology, Hong Chen Jing Huang Yue Hou Shaohua really hit the North Gate Hong Xue, Department of sacrifice things, / a /,), recent studies have shown that calcium antagonists in combination with anticancer drugs have to overcome the resistance of tumor cells and enhanced The role of anti-cancer drug activity. Bleomycin pingyangmycin he has the same characteristics, it is superior than the other anti-cancer drugs, the body has no effect on hematopoietic and immune function, however, its very obvious toxic effects, mainly can cause pulmonary fibrosis. Sometimes patients can be fixed directly to the original death. Application has been reported】 side of bleomycin induced pulmonary fibrosis in autopsy cases. That in our study, low-dose combination of verapamil and PYM, either in vitro or in vivo can enhance the anti-cancer white of PYM. So, verapamil and PYM in combination are able to improve the efficacy of the same time, the fork can reduce the toxic effects of PYM, especially in reducing the extent of pulmonary fibrosis what? This one we used calcium antagonists - - PYM verapamil alone and in combination, and a comparative study. Were divided into four groups: ① pingyangmycin alone treatment group, were treated with different doses, intraperitoneal administration. Solid-alone group ④ pingyangmycin verapamil verapamil combined with the group back to the control group. Animals were killed on a regular basis, we used light and electron microscope observation. Observations show that: pingyangmycin alone group was caused by pulmonary interstitial fibrosis, reduce the number of alveolar capillaries within a capillary micro-thrombosis, capillary lesions abundance increased with increasing dose. Verapamil monotherapy group. Significantly reduced pulmonary fibrosis. Bleomycin in combination with verapamil group, verapamil fundamental change and the same drug group alone. Lesions to a lesser extent, the lowest rate of capillary lesions. Intracellular calcium environment on cell function in large number of calcium compound is a variety of enzymes stimulated intracellular white agent, in the application of anti-cancer drug Yun, found no anticancer activity of a number of enzymes and reagents to overcome resistance to drugs potency, increased efficacy, including ca channel blockers and calmodulin inhibition of Jing. Verapamil, an anti-arrhythmia drugs, but also a specific cell membrane calcium channel blockers, calcium in the cell Ji, the amount of cells essential for cell function, verapamil to its lipophilic Example key role in the membrane, thereby to inhibit outward transport of drugs and enhanced drug accumulation in the cell, enhancing drug efficacy. Pingyang verapamil in increasing pro-tumor effects of factors Rang the same time, the accumulation can reduce the pulmonary blood. If the accumulation of lung reduction in lung disease can reduce a use which can increase the dose of PYM and improve efficacy. Our experimental results show that verapamil and PYM in combination, the lungs become places a certain degree of ease, increase the number of pulmonary capillaries, the pulmonary blood volume increase, therefore, reduced accumulation of drug in the lung , thereby reducing its pulmonary toxicity. In addition, the capillary endothelial cell damage light saddle, this is one of the reasons to reduce toxicity. / - Has been |
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