 Wysłany: Nie 11:00, 13 Mar 2011 Temat postu: vwf glt oda vza |
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| Ganglioside in acute hypoxic cortical neurons protective effect of
Injury, poisoning, can stabilize the cell membrane ganglioside given a Na , K ATPase and a Mg a - ATPase activity. To improve the ion balance. Reduce brain damage and promote functional recovery ; or reduce excitatory amino acid Majesty damage caused by secondary I students . Exogenous gangliosides on hypoxic hypoxia on decompression mechanism of brain injury research not reported , we believe that these reasons may be relevant in addition , also in the same hypoxic conditions with reduced accumulation of intracellular Ca2 And stable activity of CaM levels and CaMKinase Ⅱ related to changes we have observed that ganglioside hypoxia in rat brain cortical neurons increased rate of Ca , CaM content and CaMKinase Ⅱ decrease in activity levels , although higher than the normoxic control group, but significantly Lower than that of acute hypoxia group; hypoxia species of mouse brain tissue sections by the lipid content decreased glycosides _4J. We know , CaM and CaMKinaseII highest in brain tissue in animals , especially CaMKin & seII in the brain tissue only found in neurons . Dendrites and the postsynaptic density in vivo is particularly rich , as important components of the postsynaptic membrane . Under normal circumstances , CaM and microtubules composed of tubulin to form tubulin dimer , which is then assembled into emblem tube microtubules on neuronal axonal transport , information transfer and play an important role in nutrient transport ; CaMKinaselI also Involved in the regulation of synaptic plasticity , including synaptic plasticity and transmission combination of plasticity . The former refers to the morphological changes of synapses , the formation of new synaptic connections and the establishment of transfer functions , which repeatedly refers to synaptic activity , causing sudden changes in addition to the transmission efficiency . This solid , hypoxia give membrane ganglioside help maintain the structure and function with integrity , regulation changes in CaM and CaMKinase Ⅱ , loose tube and synapse to maintain normal structure and function , and thus play a protective hypoxic brain Important role of injury in a 【 ],[ |
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