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31] KangIC, LeeYD, KimDS. Anoveldisintegrinsalmosininhibitstumorangiogenesis [J]. CancerRes, 1999,tory burch shoes,59 (15) :3754-60. [32] GolubkovV, HawesD, MarklandFS. Anti-angiogenieactivityofcontortrostatin, adisintegrinfromAgkistrodoncontortrlxcontortrixsnakevenom [J]. Angiogenesis, 2003,keen shoes sale,6 (3) :213-24. [33] MareinkiewiezC,mbt scarpe, WeinrebPH. CalveteJJeta1. Obtustatin: apo-tentselectiveinhibitorofalphalbetalintegrininr0andanglo-genesisinvivo [J]. CancerRes,tn requin pas cher, 2003,63 (9) :2020-3. [34] Moreno-MurcianoMP, MonleonD, CalveteJJeta1. Aminoacidsequenceandhomologymodelingofobtustatin. anovelnon-RGD-containingshortdisintegrinisolatedfromthevenomofViperaleb-etinaobtusa [J]. ProteinSci, 2003.12 (2) :366-71. StructuralandfunctionalcharacterizationofsnakevenomdisintegrinsxuWei, LIZhi-qin, WUShao-yu, WUShu-guang (InstituteofPharmaceuticalScience, FirstMilitaryMedicalUniversity, Guangzhou510515, China) Abstract: Accordingtotheirpolypeptidelengthandnumberofdisulphidebonds, disintegrinsaredividedintofivegroups, includingshort-sizeddisinte · grins, medium-sizeddisintegrins, long-sizeddisintegrins, di-merledisintegrinsanddisintegrin ·-likemoleculesre. -leasedfromthedisinte 'in ·-likedomainsofP ·-IIIsnakevenommetalloproteinases. Theintegrin-inhibitoryac-tivityofdisintegrins, toinhibitplateletaggregating, cellattachingandangiogenesis, dependsontheactivetrlpeptideRGD, theappropriatepairingofcysteineres-idues,ghd italia, theaminoacidsadjacenttotheRGDmotifwith-intheintegrin ·-bindingloopandtheC. -terminusofthedisinteg-inpolypeptideslaswel1. Keywords: disintegrin; integrin; snakevenom |
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