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lin22307
PostWysłany: Pią 19:56, 18 Mar 2011    Temat postu: 补硒与锌对

补硒与锌对梭曼中毒大鼠乙酰胆碱酯酶活力和抗氧化力的影响
iemeolori~tricassay0fcll0lil妊船raseactiJ].Bu//M//Med(军事医学科学院院刊),1986,10(3):211—214.【6JJiJP,WuZB,IiuQ6,YS,YeM,Li砌.Anlll一曲Ⅲicm舡Ialyticandrapid瞅ll0dfor如mion0f~per-oxide出砌Ⅱase枷嘶[J]..,舭l,岫MedCo//(南京铁道医学院学报),1991,l0(1):27—30.【7JBredtDS,SH.onofnitricoxidesy1,acaImre溅enI-e[J].ProeⅣ(1tfUSA,1990,s7(2):682—685.·l2O·EffectofSeandZnonacetylcholinesteraseandantioxidativecapacityinsomanpoisonedratsYANGXing-Bin,YANGHui.Xuan,JIANGN,ZHAOYah2,GUXiao-G~g,HAIChun-Xu(1.DepartmentofTox/co/ogy,2.p口ofChem/stry,theFourthMed/ca/,X/饥710032,Ch/na)Abstract:AIMTostudythefeas~ofpre—ventionfromsomanintoxicationbyantioxidantsSeandZn.Ⅱ1【j[0Fortymaleratswereran—domlydividedinto4groups:controlgroup,SO-mangroup,Segroup,andZngroup.Ratsincon-trolandsomangroupswereoIaUyadministratedwith5mL·kg-1physiologicalsalineperdayf0r9d.RatsinSegroupreceived1mg‘kgNaESeO3andratsinZnonereceived4mg。kg一zincglu-conate.Exceptcontrolgroup,ratsweregivenscO.9LDs08onlallonthe10thday.After2h,theratsweresacrificed.Acetylcholinesterase(AQlE)ofwholebloodandsuperoxidedismutase(SOD),nitricoxidesynthase(NOS)activityandtotalan—tioxidativecapacity(T-AOC)of8onlallpoisonedratserum.cel~blMnlandliverweredeterminedrespectively.REqULTSAChE,SODactivityandT-AOCofratsdecreasedandNOSactivityin—ceasedat2haftersc8omsn.PretreatmentofSeandZnreducedthed眦mesinAChE,SOD,NOSac、rit、randT-AOCinducedby$oman.CON-CLUSIONSeandZnhavepreventiveeffectagainstsoInanintoxicationinrats.Keywords:soman;selenium;zinc;aeetyl-cholinesterase;antioxidativecapacity(本文编辑乔虹)
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