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Dołączył: 03 Mar 2011
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Skąd: England
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 Wysłany: Nie 18:27, 20 Mar 2011 Temat postu: GHD glätteisen gyr owo jij lbi |
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Retinol binding protein early detection of gentamicin, amikacin and tobramycin renal injury
atrmentmodelwasusedTherecallpeakserumlevelwas1.49 ± 0 +28 mg / L. Themeanpeaktimewas7.12 ± 1.17h, pharmacokineticparametersofsperfoxaclninhealthyvolunteers, plasmahalf-lifeofelimination (l /, serumclearance (CLs), volumeofappearancedistrlbation (d) andareaundercurve (AUC) were22 ± 6.83h, 8.85 = 216I / h, 273I/kg, 47. 35 - 4-10.Z4 (rag · h) / I, respectively.Within24and96h, thecumulativeurinaryrecoveryofunchangeddrugamountedto9 +16 and15.68oIthegivendoserespectively.KEYW0RDSSparfloxacin; Pharmacokinetics; HPIC (I-continued on page 149) 2.2 During the observation period, GM group, 5 cases , AMK group, 3 down, the medication after 3 to 5 days there have been qualitative testing of urine protein: protein ± ~ +, of which GM group 2 patients 14 days,[link widoczny dla zalogowanych], there is still urine protein ± ~ +. 3 discussions aminoglycoside Antibiotics are widely used in clinical practice, multiple doses, accumulation in the kidney, renal cortex and renal toxicity of drug concentration is closely related to damage of renal proximal tubule-based one. Clinical observation of urinary protein often, whether the kidney as a drug indicators of toxicity and whether to continue treatment. This protein appears in urine, often prompted severe kidney damage, sometimes evolve into irreversible renal damage. the drug caused an early mild kidney damage, protein in urine qualitative test was negative,[link widoczny dla zalogowanych], while the performance of sub-clinical level A trace proteinuria, can be used as indicators of reversible renal failure. retinol binding protein (RBP, molecular weight: 21,[link widoczny dla zalogowanych],000) is a low molecular weight protein (IMP), its main function is to transport retinol from the liver to the epithelial cells, plasma, about 90 of the RBP and thyroxine binding prealbumin (TBPA) combine to form a polymer protein complex, it is not the glomerular filtration membrane, when retinol is transported to the target cells , RBP and TBPA has lost affinity, rapidly glomerular filtration membrane, and in the renal proximal tubule reabsorption and decomposition. normally, RBP feces little displacement (about 100 ~ g/24h), However, in renal proximal tubule injury, the significant increase in urine displacement. In recent years, many studies have shown, RBP urinary displacement increases, as renal proximal tubule injury markers, and gradually applied to I clinical RBP / Cr from position, urine pH, voiding time of J, therefore, I Potamogeton fresh urine is not intended to affect the test results. This dynamic observation GM group, AMK treatment group on day 7, RBP / Cr increased in varying degrees, test values were significantly Differences with the literature reports of renal toxicity of these drugs have the same 0-phase, while the withdrawal after a week RBP / Cr no obvious difference in the increase, indicating that the conventional dose course of treatment using two drugs,[link widoczny dla zalogowanych], there is minor damage to the tubules, but the withdrawal Most can be resumed a week later, on renal proximal tubule injury is a transient slight bang, and the detection value indicates that the TOB group, the conventional dose regimen, the renal injury was not obvious past,[link widoczny dla zalogowanych], is the 3 drugs in a safer antibiotics. at the same time This also shows that EIISA urine RBP / Cr, urine protein qualitative test can be positive before the onset, that is able to early detect minor kidney damage, can be used as clinical medicine, renal proximal tubule injury in one of the reliable indicators of
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