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 Wysłany: Śro 8:32, 16 Mar 2011 Temat postu: 核磁共振用 |
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核磁共振用于蛋白质抑制剂的筛选和先导药物的发现
sfromFreztcm~sPthatinhibitDNApolymer~eB[J]．BioorgMedChem，2000，8(3)：247—250．【6JLiuD，PrasadR．WilsonSH，d口fThree-dimensionalsalufi~astructureoftheN—terminaldomainofDNApo]ymerasebetaandmappingofthessDNAinteractioninterface[J]．Biochemistry，1996，35(2O)：6188—6200．[7JmjdukPJ，bleadowslIP，FesikSWDiscoveringhi·affinityligandsforproteins[J]．Sconce，1997，278(5337)：497—4998]mjd~kPJ．MeadowsRP，FesikSWNMR·basedscreeningindrugdiscovery[J]Q胁hys，1999，皿(3)：211—240．【9iH~dukPJ，SheppardG，NettesheimDG，eta／．DiscoveryofpotentnonpeptideiahibitersofstromelyslnusingSARNMR【JJ．JAmChems。c，1997，119(17)：5818—5827．【1O]HajdukPJ，DingesJ，MikniscF，da／．NMR'baseddiscove~ofleadinhibitarsthatblockDNAbi0fthehumanpapi~umvirusE2protein[J]JChtm，1997，40(20)：3144—3150l1]HdIIkPJ，DmgesJ，Schkeryanl~JM，da／．NovelinhibitotsofErmmelhyltransferase~fromNMRandparallelsynthesis【J_．JMedChem，1999，啦(19)：3852—3859．[12]HajdukPJ，B0ydS，NetteshelmD，a／ldentifieat~a0fnovelinhibitetsoftmakinaseviaNMR-basedscreening[J]．JMedcm，20帅，43(21)：3862—3866．【13]HajdukPJ，GomtsyanA，DidomenicoS，eta／．Desi~,ofadenosinekinaseinhlbitersfromtheNMR-basedscreeningoffragments[J]JMedChem．2O0O，43(25)：4781—4786．【14]ShapiroⅢ，w~-ningJRNMRmethodsineomhimtodalthemistryJjCw'rupinChemBiol，1998，2(3)：372—375NMR．BASEDSCREENG0FPR0TEINHⅡIrI'0RSINDIUJGDISC0VERYHUHong-yu(InstituteofBiochemistryandCellBiologyChineseAcademyofSciencesShanghaiInstitutesofBiologicalSciencesShanghai200031，China)KEYWORDS：NMR；heteronuclearsinglequantumcorrelation；H／Nchemicalshift；proteininhibitor；drug
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