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 Wysłany: Pią 11:35, 25 Mar 2011 Temat postu: air jordan high heels Clinical application of calc |
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Clinical application of calcium channel blockers
Blood pressure, can reduce blood viscosity, prevent platelet aggregation, and does not affect lipid metabolism. Is the reach of other antihypertensive drugs. Making it possible to replace the B-blockers and diuretics to become the first line antihypertensive drugs. 4. Treatment of renal colic: Xia Liansheng other one with nifedipine lO ~ 20mg sublingual treatment of patients with renal colic attack patients 4l, efficiency 93%, markedly effective rate of 32, indicating a better effect on renal colic. I have on a patient with renal colic attack sublingual nifedipine lOmg treatment, the patient within 30 minutes of pain was reduced. It may be the pharmacological effects: (1) can effectively inhibit the ureteral smooth muscle cells calcium influx, reduced urinary tract smooth muscle cells 4Z · intracellular calcium, the lost feces smooth muscle relaxation, decreased sphincter} (2) can inhibit Cambodia shoot neural transmitter release. That direct inhibition of acetylcholine-induced contraction of the ureter. In addition, the drug can inhibit aldosterone secretion, promoting sodium chloride excretion, feces effect of a certain interest, is conducive to stone movement and discharge. 5. Treatment of migraine times of patients with B-blockers and tricyclic antidepressants, should consider using calcium channel blockers. 6. Treatment of irritable bowel syndrome. Verapamil, nifedipine, etc.,[link widoczny dla zalogowanych], may Road to reduce the secretion of the brain, inhibit smooth muscle contraction. domestic benzene has been reported with topiramate hole fasting nitrate sublingual treatment of irritable bowel syndrome, abdominal pain and reduce that in reducing it plays have a certain effect. 7. Treatment of shock; shock tissue oxidative metabolism, the intracellular ATP levels drop, unable to maintain ionic gradients inside and outside cells. a lot of calcium ions into the cell, intracellular calcium overload, over-Chul live on the Ca Activation of phosphatase and protease leaving tissue destruction, uncoupling of oxidative phosphorylation, destroying the normal mitochondrial function, the generation of ATP. Calcium, the lower shock patients,[link widoczny dla zalogowanych], the worse the prognosis. Calcium level in a certain way by reflecting on the degree of cell metabolism. Animal tests proved that calcium channel blockers can improve hemodynamic shock on the heart, brain, kidney and other organ ischemia arrested speech has obvious protective effect of oxygen,[link widoczny dla zalogowanych], and can improve energy metabolism. Verapamil inhibition of AV node conduction is stronger in the vasodilator effect. Generally have little effect on the myocardium. Benzene, a high degree of expansion of adjacent pyridine nitrate coronary artery and peripheral vascular, and cardiac function were not suppressed selective expansion of diltiazem leather coronary artery, usually does not cause hypotension. 8. Used in bronchial asthma; airway muscle contraction, mast cells release mediators, mucus secretion and stimulation of vagus nerve conduction, increased asthma, and these factors are related to calcium current eight-cell-related, so in recent years, research from the calcium channel blocking Delay and other agents such as nifedipine, to open up new ways of treatment of bronchial asthma. In addition, calcium channel blockers are also effective treatment of Raynaud's disease. But these drugs have their side effects, most notably inhibition of cardiac conduction, and hypotension. There are other side effects such as headache, dizziness,[link widoczny dla zalogowanych], gastrointestinal symptoms, skin itching, worsening heart failure and so on. With calcium channel blockers in a wide range of clinical applications, side effects will increase. There are also reports of these drugs can cause angina,[link widoczny dla zalogowanych], More articles related to topics：
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