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 Wysłany: Wto 20:46, 15 Mar 2011 Temat postu: 选择性RXR配Ë |
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选择性RXR配体的研究进展
inoidXreceptorligandsdifferentialbiologicalactivitiesofindividualantipodes[J]．JMedChem，2001，44(14)：2298—2303．[21]MichellysPY，ArdeckyRJ，ChenJn，eta1．Novel(2E．4E，6Z)一7一(2-alkoxy一3，5-dialkylbenzene)一3-methylocta一2，4，6-tienoicacidretinoidXreceptormodulatorsareactiveinmodelsoftype2diabetes[J]JMedChem，2003．46(13)：2683—2696．[22]GemetDL，AjamieR，ArdeckyRJ，etalDesignandsynthesisoffluorinatedRXRmodulatorsJ】．BioorgMedChemLett，2003，13(19)：3191—3195．f23]MichellysPY，BoehmMF．ChcnJY，etalDesignandsynthesisofnovelRXR—selectivemodulatorswithimprovedpharmacologicalprofile[J]．BioorgMedChemLett，2003．13(22)：4071—4075[24][25][26][27][28]MichellysPY，ArdeckyRJ，ChenJn，eta1．Design，synthesis，andstructure—activityrelationshipstudiesofnovel6，7一locked—f7一(2一alkoxv一3．5一dialkvlbenzene)一3一methylocta一2，4．6一trienoicacids{J．JMedChem，2003，46(19)：4087—4103．MichellysPY，ArrigoJD，GreseTA，eta1．Design，synthesisandstructure—activityrelationshipofnovelRXR—selectivemodulators[J]BioorgMedChemLett，2004，14：1593—1598．HaffnerCD．LenhardJM，MfilerAB，etalStructure—baseddesignofpotentretinoidXreceptoragonists[J]．JMedChem，2004，47( ：2010—2029YenWC，PrudenteRY．LamphjSynergisticeffectofaretinoidXreceptor—selectiveligandbexarotene(LGD1069，Targretin)andpaclitaxel(Taxo1)inmammarycarcinomalJ．Bre(a~tCancerResTreat．2004．88：141—148．YenWC，MannyRCorpuzMR．eta1．AselectiveretinoidXreceptoragonistbexarotene(Targretin)preventsandovercomesacquiredpaclitaxel(Taxo1)resistanceinhumannon--small·-cellLungcancer(NSCLC)[J]．ClinCancerRes，2004，10：8656—8664．
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