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 Wysłany: Czw 15:01, 24 Mar 2011 Temat postu: air jordan high heels Carbon monoxide in hepatic i |
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Carbon monoxide in hepatic ischemia / reperfusion and ischemic preconditioning of
Molecules involved in the protective effect of liver ischemic preconditioning has been reported more positive】 【4,5. Like nitric oxide, carbon monoxide is largely through the activation of soluble guanylate cyclase (sGC) induced intracellular cyclic guanosine monophosphate (cGMP)-mediated rise in the level of a series of physiological functions. Carbon monoxide also by activating the ATP dependent potassium channel induced sustained hyperpolarization, closing of calcium channels to reduce the voltage compliance of cell calcium influx,[link widoczny dla zalogowanych], reducing the level of intracellular calcium, which mediates a series of effects of J. Ischemic stimulation of the liver is rich in sensitive inducible heme oxygenase (HO-1), under the ischemic stress can produce large amounts of carbon monoxide. In the liver, carbon monoxide, the main regulator of blood flow in portal and sinusoidal system, the maintenance of perfusion of liver parenchymal cells is more critical, and systolic and diastolic function in the control of intrahepatic bile ducts. We observed that, although the I / R group also increased CO, but its magnitude is very small,[link widoczny dla zalogowanych], about 30%, while the IPC group were significantly improved liver function in the same time, CO increased very significantly, the level 4 times that of control group, is the I / R group 3 times. The results suggest that, in the I / R group of inducible heme oxygenase (HO-1) expression system, due to I / R injury and damage, so that activity decreased, so the CO levels rise less. The IPC in the I / R injury activated in advance by the CO-mediated endogenous protective mechanism,[link widoczny dla zalogowanych], CO increased significantly, to reduce liver damage. In summary, this study provides the carbon monoxide in the liver ischemic preconditioning on ischemia / reperfusion injury leads, as carbon monoxide in the exact status of this process and fine mechanisms need further study. Compared by t test. 2 results. 12.1 in each group of liver function and determination of carbon monoxide in plasma liver function results and the details of the determination of carbon monoxide in plasma results (± s) 'Group ALT (u / L) AST (u / L) LDH (u / L) CO (, umol / L) 3Control33.9 ± 5.78o. 4 ± 5.1109.0 ± 29.39.2 ± 2.6I/R277.5 ± 47.71 ¨ 623.9 ± 112.6 !: Guyana:::! Guyana  :,[link widoczny dla zalogowanych]! Kyu Yi:::: Guyana: wall: Note: 1) Control group P <0.052) and the I / 'R group P <0.0552. 2, the control group lobule liver histology, liver cells, sinusoidal endothelial and vascular morphology, 6 with normal structure; I / R group, the liver cells, endothelial cells appeared cloudy swelling, degeneration, sinusoidal congestion significantly, the neutrophils were seen aggregation; IPC degeneration of liver cells and significantly less sinusoidal congestion in the I / R group. * 45 *
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