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Mitochondrial damage and neuronal ischemic death
): 34l4-3422.27SiesioBK, EImerE. JanelidzeS. eta1. Roleandmechanismsofseocondarymitochondrialfailure. ActaNeurochkSuppl (wien). 1999.73:7 a l3.28MatsumotoS, Fr ~ ergFe ~ and-DrakeM,[link widoczny dla zalogowanych], eta1. Blockadeofthemitochondrialpermeabilitytransitionporediminisheshafarctsizeintherataftertransientmiddlecerebralarteryocclusion. JCerebBloodFlowMetab, 1999, l9 (7) :736-741. (Received: 4-17 Revised 2002: 2002 ~ 8-26) tPA treatment of menstrual women,[link widoczny dla zalogowanych], according to the relative safety of medical newsletter reported cases of Stroke and recent literature review on women in the menstrual tissue-type plasminogen activator (tPA) therapy appears to be safe. In theory, women's menstrual period is a contraindication for intravenous tPA treatment. To assess the menstruating women with acute ischemic stroke, intravenous tPA treatment safety, Wein and other menstrual period for 1 patient in the right side of hemiparesis associated with speech and dysarthria were the 46-year-old woman tPA treatment, she found All other indications of thrombolytic therapy, prior to the tPA have to consider the possibility of increased bleeding, the worst case is the need for emergent hysterectomy. The results showed that after application of tPA in patients with menstrual flow began 2h significant increase in blood pressure, intravenous fluids can increase blood pressure, low blood pressure appeared after 4h of hemoglobin and hematocrit also decreased, the import volume of red cells returned to normal after the 12h period The patient recovered well only mild dysfunction left. Wein and others also made a literature review,[link widoczny dla zalogowanych], conducted on Medline and PubMed search found 25 female patients had menstrual period due to myocardial infarction or deep vein thrombosis for thrombolytic therapy have found no serious adverse reactions, only 2 patients required blood transfusion. United States National Institute of Neurological Disorders and Stroke (NINDS) database review found that 5 cases of stroke in women, menstrual received tPA treatment, 2 patients had adverse reactions, including 1 patient had a history of dysfunctional uterine bleeding, the need of emergency Uterine artery embolization. weiI1 so that the menstrual period is not a contraindication for thrombolytic therapy, patients should not be delayed in thrombolysis menstrual period. However, increased menstrual flow after thrombolytic therapy or during menstruation when the 1st day for thrombolysis should be a blood transfusion. For those who have a history of dysfunctional uterine bleeding in patients with thrombolytic therapy should be cautious,[link widoczny dla zalogowanych], because they might need emergency surgery. (Qu Dong Feng) men and women are different symptoms of stroke, according to a recent AnnalsofEmergencyMedicine reports, doctors and nurses should pay attention to gender differences in stroke symptoms, awareness of female stroke patients often change and there is non-specific pain complaints. Morgenstern and other stroke patients studied 1189 cases of first symptoms to treatment was analyzed, and these symptoms are divided into 14 categories. The results showed that 28% of women showed symptoms do not meet the traditional, while men only 19% (OR, 1.62; 95% CI, 1.1 ~ 2.2); women altered consciousness (17% vs 12% ) and pain (12% vs 8%) and the like more common symptoms than men, while men were in the traditional symptoms such as imbalance (20% vs 15%) and hemiplegia (24% vs 19%) is more common. In addition, more women than men showed neurological symptoms (21% vs 17%) of the trend, and abnormal gait men seem more common than women (11% vs 8% o If this sex difference was further confirmed ,[link widoczny dla zalogowanych], emergency physicians and emergency room nurses and doctors in charge of sorting should be receiving education in this area, recognizing that unlike acute stroke in women, usually presents as traditional male symptoms, special attention should be asked to women patients, and check local weakness, sensory loss, abnormal speech or understanding, and (or) ataxia, to identify potential stroke. of female stroke patients for rapid sorting and diagnosis to treatment success. (Qu Dong Feng)
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