yxgaxjlywf
helikopter
Dołączył: 03 Mar 2011
Posty: 735
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Skąd: England
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 Wysłany: Śro 13:39, 09 Mar 2011 Temat postu: mbt scarpe rhd fej hnt hpf |
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The clinical characteristics of elderly patients with acute leukemia and its clinical efficacy
Third, the discussion of the elderly in recent years, increasing year by year AL 3], I asked admitted to hospital in the past 4 years, 68 patients aged AL, accounting for the same period of acute and chronic leukemia patients aged 66.7% and accounting for 18% of adult AL,[link widoczny dla zalogowanych], which AML mainly typing in,[link widoczny dla zalogowanych], ~ k 69.5%, with the literature 3] basically the same. AIJ elderly patients compared with young adults, many accompanied by cardiovascular and cerebrovascular disease, diabetes, liver,[link widoczny dla zalogowanych], lung disease, associated with 2 tumors in 1 case, treatment is easy with severe infection, internal bleeding and DIC, is the main reason for early death . About 80% of patients with different degrees of immune dysfunction and liver and kidney damage. Elderly patients with these unique biological and clinical features may be a poor response to conventional chemotherapy, the main factor of poor prognosis. Chemotherapy in this group of 6o patients CR rate 58.3% 66.7% total efficiency,[link widoczny dla zalogowanych], which AMLCR rate of 56.0%, significantly higher than other domestic reported 23.9% and 30.2% [3,43 . Chemotherapy is still the most important means of AIJ elderly patients, we used force in recent years, the treatment of AML14 patients, CR was slightly higher than other programs, but no statistical significance. Replaced by vincristine vindesine,[link widoczny dla zalogowanych], with IDA replace other anthracycline chemotherapy drugs, to improve the efficacy of L A working more and more common by everyone; but costs more, bone marrow suppression and long, the need for cytokines, strong support components such as blood transfusion, bone marrow suppression can be spent on security. British scholar recently reported 1065 cases of elderly patients with cytogenetic classification of AML can 【prognosis. As with t (15; l7), t (8; 21), inv (16) persons, a good prognosis, CR rate was 72%, anti-therapeutic 8% and the recurrence risk is 56%. The normal karyotype, chromosomal abnormalities and other non-composite composite CR rate of chromosomal abnormalities were 68%, 53% and 26%, anti-therapy 17%, respectively, 30% and 56%, the risk of recurrence was 78%, respectively, 85% and 9l%. Chromosome detection rate in this group less hard to compare, 1 cases with complex chromosomal abnormalities in AML-M2 patients with disease-free survival and overall survival were 9 and l2 months, while the other 1 case of t (8; 21) abnormalities in patients with AML-M4a 2 months without remission. Ferrara and Mirto ~ 6] reported that> 60-year-old AML patients, serum LDH> 6.7tLrnol · S · L was significantly associated with poor prognostic indicators, is also significantly affect disease-free survival of only one parameter, this LDH> 6. 7tnnol · S · L and <6.7tLrnol · s · L cR rate of the two groups were different, 1-year disease-free survival is similar, because the number of cases was small, it is worth further observation.
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