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 Wysłany: Sob 7:57, 26 Mar 2011 Temat postu: mbt hommes Cirrhosis patients IL-6, TNF-α clinica |
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Cirrhosis patients IL-6, TNF-α clinical significance
20--58 years, mean (47 ± 7. years. Classified according to Child-Pugh classification: A 13 cases of grade, B grade 24 cases,[link widoczny dla zalogowanych], C grade in 19 cases. Where B, C grade in 43 cases classified according to whether abdominal infection: infection in 12 cases,[link widoczny dla zalogowanych], 31 cases of non-infected group. Control group,[link widoczny dla zalogowanych], 20 were healthy. Detection methods are used double antibody sandwich ELISA. IL-6 kit (Netherlands Hbt company). TNF-a kit (France DIACLD Ⅵ companies). Operations are conducted in strict accordance with the instructions. Statistical analysis using t test. 2. Results Serum IL-cirrhotic patients 6,[link widoczny dla zalogowanych], TNF-a levels were significantly higher (P <0.001), and according to Child-Pugh classification and the severity of liver function was consistent, in which the level of IL-6, B level (369 ± 6.7) pedro1 than A-level (19.2 ± 4.9) pg/m1 were significantly different (P <0001), c-level (612 ± 17,4) pgfm1 than the B level were significantly different ( P <O.oo1). TNF-a levels in the B-level (34.5 ± 11. pg/m1 than A-level (18.1 ± 4.6) pedro | were significantly different (P <0.001), C grade (41. 1 ± 85) pg, m1 is different than the B level (P <0.05). Cirrhosis abdominal infection serum IL-6, TNF-a levels than non-infected patients were significantly higher (P <0.13131), see table. Schedule of serum IL-6, TNF-a and cirrhosis Taiwan wells abdominal infection {i ± 5) 3. Discussion of IL-6 and TNF-is a complex multi-cellular sources and biological functions of cytokines. Inflammatory response in vivo pathophysiological process and a series of important medium. (LPS) role in promoting monocyte macrophages, endothelial cells, liver cells and other cells to produce IL-6,71 NF-a and so on. and 71NF-d, LPS is a strong IL-6 inducer, there positive regulatory role in the formation of a strong role in the cytokine network. so as to promote liver inflammation. mediated liver cell injury and fibrosis induced, therefore, IL a 6, TNF-levels can reflect the situation of liver inflammation and fibrosis . Our results show that IL-6 and TNF-n levels and cirrhosis-related Child-Pugh classification. (Hint IL-6, TN'F-a cirrhosis of liver dysfunction with increased levels increase). and Tily and other similar results. Byl Proposed increased levels of serum IL-6 in the early to determine whether the infected liver cirrhosis, 89% specificity, 100% sensitivity. The results of this paper shows abdominal infection in cirrhosis of serum IL-6, TNF-a were significantly increased. Chen Kai Hung et al reported that the domestic line. Tip abdominal infection in determining the cirrhosis, IL a 6, TNF-a in serum has clinical value.
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