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Dołączył: 03 Mar 2011
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 Wysłany: Wto 4:49, 08 Mar 2011 Temat postu: mbt shoes italia bcn tgi hup rxw |
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Acanthosis nigricans associated with three cases of gastric cancer
67g / L, fecal occult blood test (+). Lower leg skin biopsy showed: squamous papilloma with mild to moderate hyperplasia,[link widoczny dla zalogowanych], epidermal hyperkeratosis, acanthosis hypertrophy and atrophy secondary alternated, melanin found in full-thickness skin, consistent with AN. B-said: cardia, fundus cancer, abdominal and post Author: 310003,[link widoczny dla zalogowanych], Hangzhou, Zhejiang University School of Medicine Department of Endocrinology, First Affiliated Hospital, Correspondence to: Shen Jianguo. Email: jgshen @ medmai ~ com. cn. Case report. Multiple peritoneal lymph nodes (large by 2.2cm × 2.9cm). Large ulcers and gastric endoscopy showed cardiac involvement, pathology showed gastric adenocarcinoma. Diagnosis of Discussion is divided into benign and malignant AN. AN can be a benign idiopathic, genetic, or endocrine diseases and drug-related, skin lesions range of small, have a certain self-limiting, some patients may be self-healing. AN rapid development of malignant lesions, severe and extensive, was not limited to thickening of the pigmented skin lesions, mucous membranes and mucocutaneous junctions have typical skin lesions,[link widoczny dla zalogowanych], eye and lip Zhou papilloma hyperplasia, brittle nails with longitudinal ridge, and the palms and soles are characteristic that Leaer-Trelat symptoms, natural red skin papillomatosis and hyperkeratosis of palms and soles, almost 100% associated with internal cancers, most of the predilection of gastric adenocarcinoma (55% a 61%), skin lesions and cancer accounted for 61 simultaneous %, the tumor before the lesions were 22%, skin lesions before cancer accounted for 17%. 3 cases of malignant AN in this group were combined gastric adenocarcinoma, which were identified cancer treatment because of rash, showing the diagnosis of malignant tumor AN extremely valuable. Early lesions often associated with tumor metastasis, and patient survival compared with the same tumor but not skin lesions were shorter. If clinicians can promptly identify the lesions, especially lesions of multiple treatment or no improvement and there were more severe weight loss or gastrointestinal symptoms occur, should be promptly performed an endoscopy and colonoscopy,[link widoczny dla zalogowanych], so early detection of cancer lesions and timely surgery, the tumor and the prognosis of lesions is expected to well. Cause is not clearly malignant AN, malignant tumors may have some substance, such as male hormones and a variety of peptides, such substances in the cell receptor level with insulin-like activity, directly or indirectly induced ANL4.5J. Because of skin lesions and cancer are closely related, severe skin lesions increases the tumor,[link widoczny dla zalogowanych], tumor resection lesions could fade or disappear temporarily. 2 cases of skin lesions in this group were improved by surgery. AN principle of treatment of malignant primary disease as early as possible to find and remove the tumor and the use of drug treatment.
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