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 Wysłany: Czw 9:32, 17 Mar 2011 Temat postu: tory burch shoes vnr nmp tdx shl |
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Prime Venom structural features of dissociation and its relationship with the biological activity
31] KangIC, LeeYD, KimDS. Anoveldisintegrinsalmosininhibitstumorangiogenesis [J]. CancerRes, 1999,[link widoczny dla zalogowanych],59 (15) :3754-60. [32] GolubkovV, HawesD, MarklandFS. Anti-angiogenieactivityofcontortrostatin, adisintegrinfromAgkistrodoncontortrlxcontortrixsnakevenom [J]. Angiogenesis, 2003,[link widoczny dla zalogowanych],6 (3) :213-24. [33] MareinkiewiezC,[link widoczny dla zalogowanych], WeinrebPH. CalveteJJeta1. Obtustatin: apo-tentselectiveinhibitorofalphalbetalintegrininr0andanglo-genesisinvivo [J]. CancerRes,[link widoczny dla zalogowanych], 2003,63 (9) :2020-3. [34] Moreno-MurcianoMP, MonleonD, CalveteJJeta1. Aminoacidsequenceandhomologymodelingofobtustatin. anovelnon-RGD-containingshortdisintegrinisolatedfromthevenomofViperaleb-etinaobtusa [J]. ProteinSci, 2003.12 (2) :366-71. StructuralandfunctionalcharacterizationofsnakevenomdisintegrinsxuWei, LIZhi-qin, WUShao-yu, WUShu-guang (InstituteofPharmaceuticalScience, FirstMilitaryMedicalUniversity, Guangzhou510515, China) Abstract: Accordingtotheirpolypeptidelengthandnumberofdisulphidebonds, disintegrinsaredividedintofivegroups, includingshort-sizeddisinte · grins, medium-sizeddisintegrins, long-sizeddisintegrins, di-merledisintegrinsanddisintegrin ·-likemoleculesre. -leasedfromthedisinte 'in ·-likedomainsofP ·-IIIsnakevenommetalloproteinases. Theintegrin-inhibitoryac-tivityofdisintegrins, toinhibitplateletaggregating, cellattachingandangiogenesis, dependsontheactivetrlpeptideRGD, theappropriatepairingofcysteineres-idues,[link widoczny dla zalogowanych], theaminoacidsadjacenttotheRGDmotifwith-intheintegrin ·-bindingloopandtheC. -terminusofthedisinteg-inpolypeptideslaswel1. Keywords: disintegrin; integrin; snakevenom
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